Endocrine Abstracts

There is accumulating epidemiological evidence that a physically active life plays an independent role in the protection against type 2 diabetes, cardiovascular diseases, cancer, dementia and even depression. For most of the last century, researchers sought a link between muscle contraction and humoral changes in the form of an ‘exercise factor', which could be released from skeletal muscle during contraction and mediate some of the exercise-induced metabolic changes in o...

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Decades of clinical experience and research in human and non-human primates demonstrate that maternal care received early in life strongly influences the development of parenting and other social skills as well as resiliency in the face of stress. Analogous intergenerational effects of maternal nurturing have recently been reported in rats. Adult stress responses (anxiety and hypothalamic-pituitary-adrenal axis activation) are inversely related to the amount of maternal lickin...

Chronic low-grade systemic inflammation is a feature of chronic diseases such as cardiovascular disease and type 2 diabetes. Regular exercise offers protection against all-cause mortality, primarily by protection against atherosclerosis and insulin resistance and there is evidence that physical training is effective as a treatment in patients with chronic heart diseases and type 2 diabetes. Regular exercise induces anti-inflammatory actions. During exercise, IL-6 (interleukin-...

Context: Obesity is accompanied by blunted GH secretion but relatively normal serum IGF-I levels, which suggests increased GH sensitivity. This, however, remains to be tested at the level of GH signaling in human subjects.Objective: To compare the effects of an acute intravenous GH bolus in obese vs normal weight subjects on GH signaling pathways in adipose and muscle tissue, substrate metabolism and insulin sensitivity.Subjects an...

Background: The NordiNet® International Outcome Study (IOS) (NCT00960128), a non-interventional study (2006–2016), assessed the effectiveness and safety of real-life treatment with Norditropin®. Out of 20,548 enrolled patients, 20,195 (paediatric/adult; 17,711/2484) were included in the full analysis set (FAS) and 12,938 (11,967/971) in the effectiveness analysis set (EAS). Outcomes were assessed in children with growth hormone deficiency (...

Objectives: Congenital heart disease, especially pulmonary stenosis, is a frequent comorbidity in patients with Noonan syndrome (NS). Patients with NS are also at increased risk of childhood leukaemia and solid tumours. Among solid tumours, brain tumours, including glioneuronal tumours, have been described in younger patients but remain rare. Current safety data do not indicate an association of growth hormone (GH) therapy with increased risk for development or progression of ...

BackgroundSurgical resection is indicated in patients with non-functioning pituitary adenomas (NFPA) causing visual defects or tumor growth in proximity to the optic chiasm. The aim of this study was to systematically assess the benefits and harms of pituitary endocrine function after transsphenoidal surgery in patients with NFPAs.MethodsThis study was conducted a systematic review that searched for potential...

Bispenol A (BPA) is a chemical often integrated in impact-resistant plastics and surface coatings in canned foods as well as screw-on caps and cashier receipts. BPA is either intentionally added or appear as a consequence of recycling in materials with food contact, which leaves consumers at risk of exposure. BPA has known endocrine disrupting effects and is suspected to be a contributing factor in disorders such as overweight, diabetes, cardiovascular diseases, and behavioral...

ESE Young Investigator AwardBackground: It is still discussed if subclinical hyperthyroidism and ‘high-normal’ thyroid function are risk-factors for cardiovascular mortality.Objectives: To examine the risk of cardiovascular and all-cause mortality in relation to subclinical hyperthyroidism.Methods: Patients consulting their general practitioner from 2000 to 2009 in Copenhagen, Denmark, who ...